Publications (1999-2006)

Halpern, HJ, Chandramouli, GVR, Barth, ED, Yu, C, Peric, M, Grdina, DJ, and Teicher, BA, Diminished aqueous microviscosity of tumors in murine models measured with in vivo radiofrequency electron paramagnetic resonance. Cancer Research, 1999.59(22): p. 5836-5841

Pou, S, Halpern, HJ, Tsai, P, and Rosen, GM, Issues pertinent to the in vivo in situ spin trapping of free radicals. Accounts of Chemical Research, 1999. 32(2): p. 155-161

Pou, S, Tsai, P, Porasuphatana, S, Halpern, HJ, Chandramouli, GVR, Barth, ED, and Rosen, GM, Spin trapping of nitric oxide by ferro-chelates: kinetic and in vivo pharmacokinetic studies.  Biochimica Et Biophysica Acta-General Subjects, 1999.1427(2): p. 216-226

Rinard, GA, Quine, RW, Harbridge, JR, Song, RT, Eaton, GR, and Eaton, SS, Frequency dependence of EPR signal-to-noise. Journal of Magnetic Resonance, 1999. 140(1): p. 218-227

Rinard, GA, Quine, RW, Song, RT, Eaton, GR, and Eaton, SS, Absolute EPR spin echo and noise intensities. Journal of Magnetic Resonance, 1999. 140(1): p. 69-83

Rosen, GM, Pou, S, Cohen, MS, Hassett, DJ, Britigan, BE, Barber, MJ, Cao, GL, Cosby, K, Sturgeon, BE, and Halpern, HJ, N-14-spin trapping of free radicals in the presence of N-15-spin labeled Neisseria gonorrhoeae. Journal of the Chemical Society-Perkin Transactions 2, 1999(2): p. 297-300

Zhou, Y, Bowler, BE, Eaton, GR, and Eaton, SS, Electron spin lattice relaxation rates for S=1/2 molecular species in glassy matrices or magnetically dilute solids at temperatures between 10 and 300 K. Journal of Magnetic Resonance, 1999. 139(1): p. 165-174

Eaton, GR and Quine, RW, Comparison of four digitizers for time-domain EPR. Applied Spectroscopy, 2000. 54(10): p. 1543-1545

Eaton, SS and Eaton, GR, Relaxation Times of Organic Radicals and Transition Metal Ions, in Biological Magnetic Resonance. 2000, Kluwer Academic/Plenum Publishers: New York.

Margolis, AS, Porasuphatana, S, and Rosen, GM, Role of paraquat in the uncoupling of nitric oxide synthase. Biochimica Et Biophysica Acta-General Subjects, 2000. 1524(2-3): p. 253-257

Rinard, GA, Quine, RW, and Eaton, GR, An L-band crossed-loop (bimodal) EPR resonator. Journal of Magnetic Resonance, 2000. 144(1): p. 85-88

Rosen, GM, Tsai, P, Barth, ED, Dorey, G, Casara, P, Spedding, M, and Halpern, HJ, A one-step synthesis of 2-(2-pyridyl)-3H-indol-3-one N-oxide: Is it an efficient spin trap for hydroxyl radical? Journal of Organic Chemistry, 2000. 65(14): p. 4460-4463

Tsai, P, Porasuphatana, S, Pou, S, and Rosen, GM, Investigations into the spin trapping of nitric oxide and superoxide: models to explore free radical generation by nitric oxide synthase. Journal of the Chemical Society-Perkin Transactions 2, 2000. 5: p. 983-988

Zhang, B, Cao, GL, Domachowske, J, Jackson, MJ, Porasuphatana, S, and Rosen, GM, Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells. Analytical Biochemistry, 2000. 286(2): p. 198-205

Eaton, GR, Eaton, SS, Stoner, JW, Quine, RW, Rinard, GA, Smirnov, AI, Weber, RT, Krzystek, J, Hassan, AK, Brunel, LC, and Demortier, A, Multifrequency electron paramagnetic resonance of ultramarine blue. Applied Magnetic Resonance, 2001. 21(3-4): p. 563-570

Kang, UJ, Nakamura, K, Bindokas, VP, Kowlessur, D, Elas, M, Milstein, S, Marks, JD, and Halpern, HJ, Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. Journal of Biological Chemistry, 2001. 276(37): p. 34402-34407

Porasuphatana, S, Tsai, P, Pou, S, and Rosen, GM, Involvement of the perferryl complex of nitric oxide synthase in the catalysis of secondary free radical formation. Biochimica Et Biophysica Acta-General Subjects, 2001. 1526(1): p. 95-104

Porasuphatana, S, Weaver, J, Budzichowski, TA, Tsai, P, and Rosen, GM, Differential effect of buffer on the spin trapping of nitric oxide by iron chelates. Analytical Biochemistry, 2001. 298(1): p. 50-56

Rosen, GM, Stuehr, D, and Pou, S, Oxygen reduction by nitric-oxide synthases. Journal of Biological Chemistry, 2001.276(18): p. 14533-14536

Thohan, S, Zurich, MC, Chung, H, Weiner, M, Kane, AS, and Rosen, GM, Tissue slices revisited: Evaluation and development of a short-term incubation for integrated drug metabolism. Drug Metabolism and Disposition, 2001. 29(10): p. 1337-1342

Tsai, P, Elas, M, Parasca, AD, Barth, ED, Mailer, C, Halpern, HJ, and Rosen, GM, 5-Carboxy-5-methyl-1-pyrroline N-oxide: a spin trap for the hydroxyl radical. Journal of the Chemical Society-Perkin Transactions 2, 2001(6): p. 875-880

Yong, L, Harbridge, J, Quine, RW, Rinard, GA, Eaton, SS, Eaton, GR, Mailer, C, Barth, E, and Halpern, HJ, Electron spin relaxation of triarylmethyl radicals in fluid solution. Journal of Magnetic Resonance, 2001. 152(1): p. 156-161

Macdonald, RL, Zhang, ZD, Curry, D, Elas, M, Aihara, Y, Halpern, H, Jahromi, BS, and Johns, L, Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates. Neurosurgery, 2002. 51(3): p. 761-768

Porasuphatana, S, Tsai, P, Pou, S, and Rosen, MG, Perferryl complex of nitric oxide synthase: role in secondary free radical formation. Biochimica Et Biophysica Acta-General Subjects, 2002. 1569(1-3): p. 111-116

Quine, RW, Rinard, GA, Eaton, SS, and Eaton, GR, A pulsed and continuous wave 250 MHz electron paramagnetic resonance spectrometer. Concepts in Magnetic Resonance, 2002. 15(1): p. 59-91.John Wiley & Sons Inc.

 Reddy, TJ, Iwama, T, Halpern, HJ, and Rawal, VH, General synthesis of persistent trityl radicals for EPR imaging of biological systems. Journal of Organic Chemistry, 2002. 67(14): p. 4635-4639

Rinard, GA, Ouine, RW, Eaton, GR, and Eaton, SS, Adapting a hall probe controller for current control of an air-core magnet. Concepts in Magnetic Resonance, 2002. 15(1): p. 47-50

Rinard, GA, Quine, RW, Eaton, GR, and Eaton, SS, 250 MHz crossed-loop electron paramagnetic resonator for pulsed resonance. Concepts in Magnetic Resonance, 2002. 15(1): p. 37-46.John Wiley & Sons Inc.

Rinard, GA, Quine, RW, Eaton, GR, Eaton, SS, Barth, ED, Pelizzari, CA, and Halpern, HJ, Magnet and gradient coil system for low-field EPR imaging. Concepts in Magnetic Resonance, 2002. 15(1): p. 51-58.John Wiley & Sons Inc.

Rinard, GA, Quine, RW, Eaton, S, and Eaton, GR, Frequency dependence of EPR signal intensity, 250 MHz to 9.1 GHz. Journal of Magnetic Resonance, 2002. 156(1): p. 113-121

Rinard, GA, Quine, RW, Eaton, SS, and Eaton, GR, Frequency dependence of EPR signal intensity, 248 MHz to 1.4 GHz. Journal of Magnetic Resonance, 2002. 154(1): p. 80-84

Rosen, GM, Tsai, P, and Pou, S, Mechanism of free-radical generation by nitric oxide synthase. Chemical Reviews, 2002.102(4): p. 1191-1199

Rosen, GM, Tsai, P, Weaver, J, Porasuphatana, S, Roman, LJ, Starkov, AA, Fiskum, G, and Pou, S, The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. Journal of Biological Chemistry, 2002. 277(43): p. 40275-40280

Tsai, P, Porasuphatana, S, Halpern, HJ, Barth, ED, and Rosen, GM, In vivo in situ detection of nitric oxide using low-frequency EPR spectroscopy. Methods Mol Biol, 2002. 196: p. 227-37

Weaver, J, Porasuphatana, S, Tsai, P, Cao, GL, Budzichowski, TA, Roman, LJ, and Rosen, GM, The activation of neuronal nitric-oxide synthase by various divalent cations. Journal of Pharmacology and Experimental Therapeutics, 2002. 302(2): p. 781-786

Williams, BB, al Hallaq, H, Chandramouli, GVR, Barth, ED, Rivers, JN, Lewis, M, Galtsev, VE, Karczmar, GS, and Halpern, HJ, Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: Correlation with BOLD MRI. Magnetic Resonance in Medicine, 2002. 47(4): p. 634-638

Yuan, CS, Shao, ZH, Vanden Hoek, TL, Qin, YM, Becker, LB, Schumacker, PT, Li, CQ, Dey, L, Barth, E, Halpern, H, and Rosen, GM, Baicalein attenuates oxidant stress in cardiomyocytes. American Journal of Physiology-Heart and Circulatory Physiology, 2002. 282(3): p. H999-H1006

Zhang, B, Cao, GL, Cross, A, Domachowske, JB, and Rosen, GM, Differential antibacterial activity of nitric oxide from the immunological isozyme of nitric oxide synthase transduced into endothelial cells. Nitric Oxide-Biology and Chemistry, 2002.7(1): p. 42-49

Al-Hallaq, HA, Zamora, MA, Fish, BL, Halpern, HJ, Moulder, JE, and Karczmar, GS, Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients. Oxygen Transport to Tissue Xxiv, 2003.530: p. 433-440

Elas, M, Parasca, A, Grdina, DJ, and Halpern, HJ, Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 2003.1637(2): p. 151-155

Elas, M, Williams, BB, Parasca, A, Mailer, C, Pelizzari, CA, Lewis, MA, River, JN, Karczmar, GS, Barth, ED, and Halpern, HJ, Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): Methodology and comparison with blood oxygen level-dependent (BOLD) MRI. Magnetic Resonance in Medicine, 2003. 49(4): p. 682-691

Halpem, HJ, Applications of in Vivo EPR Spectroscopy and Imaging in Cancer Research, in In Vivo EPR (ESR): Theory and Applications., LJ Berliner, Editor. 2003, Kluwer Academic/Plenum Publishers: New York, NY. p. 469-482.

Huang, Y, Nan, AJ, Rosen, GM, Winalski, CS, Schneider, E, Tsai, P, and Ghandehari, H, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-linked nitroxides: Potential magnetic resonance contrast agents. Macromolecular Bioscience, 2003. 3(11): p. 647-652

 Mailer, C, Robinson, BH, Williams, BB, and Halpern, HJ, Spectral fitting: The extraction of crucial information from a spectrum and a spectral image. Magnetic Resonance in Medicine, 2003. 49(6): p. 1175-1180

 Porasuphatana, S, Tsai, P, and Rosen, GM, The generation of free radicals by nitric oxide synthase. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, 2003. 134(3): p. 281-289

Rosen, GM, Porasuphatana, S, Tsai, P, Ambulos, NP, Galtsev, VE, Ichikawa, K, and Halpern, HJ, Dendrimeric-containing nitronyl nitroxides as spin traps for nitric oxide: Synthesis, kinetic, and stability studies. Macromolecules, 2003. 36(4): p. 1021-1027

Swartz, HM, Khan, N, Wilmot, CM, Rosen, GM, Demidenko, E, Sun, J, Joseph, J, O'Hara, J, and Kalyanaraman, B, Spin traps: In vitro toxicity and stability of radical adducts. Free Radical Biology and Medicine, 2003. 34(11): p. 1473-1481

Tsai, P, Ichikawa, K, Mailer, C, Pou, S, Halpern, HJ, Robinson, BH, Nielsen, R, and Rosen, GM, Esters of 5-carboxyl-5-methyl-1-pyrroline N-oxide: A family of spin traps for superoxide. Journal of Organic Chemistry, 2003. 68(20): p. 7811-7817

Dreher, MR, Elas, M, Ichikawa, K, Barth, ED, Chilkoti, A, Rosen, GM, Halpern, HJ, and Dewhirst, M, Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Medical Physics, 2004. 31(10): p. 2755-2762

Goldstein, S, Rosen, GM, Russo, A, and Samuni, A, Kinetics of spin trapping superoxide, hydroxyl, and aliphatic radicals by cyclic nitrones. Journal of Physical Chemistry A, 2004. 108(32): p. 6679-6685

Kao, JPY and Rosen, GM, Esterase-assisted accumulation of 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl into lymphocytes. Organic & Biomolecular Chemistry, 2004. 2(1): p. 99-102

Nielsen, RD, Canaan, S, Gladden, JA, Gelb, MH, Mailer, C, and Robinson, BH, Comparing continuous wave progressive saturation EPR and time domain saturation recovery EPR over the entire motional range of nitroxide spin labels. Journal of Magnetic Resonance, 2004. 169(1): p. 129-163

Owenius, R, Terry, GE, Williams, MJ, Eaton, SS, and Eaton, GR, Frequency dependence of electron spin relaxation of nitroxyl radicals in fluid solution. Journal of Physical Chemistry B, 2004. 108(27): p. 9475-9481

Raines, K, Cao, GL, Rosen, G, and Shapiro, P, Effects of neuronal nitric oxide synthase generated nitric oxide on extracellular signal-regulated kinases (ERK) and cell proliferation. Faseb Journal, 2004. 18(8): p. C274-C274

Raines, KW, Cao, GL, Porsuphatana, S, Tsai, P, Rosen, GM, and Shapiro, P, Nitric oxide inhibition of ERK1/2 activity in cells expressing neuronal nitric-oxide synthase. Journal of Biological Chemistry, 2004. 279(6): p. 3933-3940

Rosen, GM, Beselman, A, Tsai, P, Pou, S, Mailer, C, Ichikawa, K, Robinson, BH, Nielsen, R, Halpern, HJ, and MacKerell, AD, Influence of conformation on the EPR spectrum of 5,5-dimethyl-1-hydroperoxy-1-pyrrolidinyloxyl: A spin trapped adduct of superoxide. Journal of Organic Chemistry, 2004. 69(4): p. 1321-1330

Rosen, GM, Weaver, J, Tsai, P, and Pou, S, Superoxide dismutase versus ferricytochrome C: Determining rate constants for the spin trapping of superoxide by cyclic nitrones. Journal of Organic Chemistry, 2004. 69(24): p. 8423-8428

Stoner, JW, Szymanski, D, Eaton, SS, Quine, RW, Rinard, GA, and Eaton, GR, Direct-detected rapid-scan EPR at 250 MHz. Journal of Magnetic Resonance, 2004. 170(1): p. 127-135

Weaver, J, Porasuphatana, S, Tsai, P, Cao, GL, Budzichowski, TA, Roman, LJ, and Rosen, GM, The effect of divalent cations on neuronal nitric oxide synthase activity. Toxicological Sciences, 2004. 81(2): p. 325-331

Williams, BB and Halpem, HJ, Applications of in Vivo EPR Spectroscopy and Imaging in Cancer research, in Biomedical EPR - Part A: Free Radicals, Metals, Medicine and Physiology, GR Eaton and SS Eaton, Editors. 2004, Kluwer Academic/Plenum Publishers: New York.

Baillie, L, Hibbs, S, Tsai, P, Cao, GL, and Rosen, GM, Role of superoxide in the germination of Bacillus anthracis endospores. Fems Microbiology Letters, 2005. 245(1): p. 33-38

Bowman, MK, Mailer, C, and Halpern, HJ, The solution conformation of triarylmethyl radicals. Journal of Magnetic Resonance, 2005. 172(2): p. 254-267

Eaton, GR, Joshi, JP, and Eaton, SS, Impact of resonator on direct-detected rapid-scan EPR at 9.8 GHz. Applied Magnetic Resonance, 2005. 28(3-4): p. 239-249

Fielding, AJ, Carl, PJ, Eaton, GR, and Eaton, SS, Multifrequency EPR of four triarylmethyl radicals. Applied Magnetic Resonance, 2005. 28(3-4): p. 231-238

Joshi, JP, Ballard, JR, Rinard, GA, Quine, RW, Eaton, SS, and Eaton, GR, Rapid-scan EPR with triangular scans and fourier deconvolution to recover the slow-scan spectrum. Journal of Magnetic Resonance, 2005. 175(1): p. 44-51

Owenius, R, Eaton, GR, and Eaton, SS, Frequency (250 MHz to 9.2 GHz) and viscosity dependence of electron spin relaxation of triarylmethyl radicals at room temperature. Journal of Magnetic Resonance, 2005. 172(1): p. 168-175.Academic Press Inc Elsevier Science.

Quine, RW, Eaton, SS, and Eaton, GR, Pulsed saturation recovery 250 MHz electron paramagnetic resonance spectrometer. Concepts in Magnetic Resonance Part B-Magnetic Resonance Engineering, 2005. 26B(1): p. 23-27

Raines, K, Hibbs, S, Cao, GL, Weaver, J, Baillie, L, and Rosen, G, Bacillus anthracis regulation of nitric oxide production by nitric oxide synthase in a macrophage model. Free Radical Biology and Medicine, 2005. 39: p. S91-S91

Rosen, GM, Sr, B, Kohr, MJ, and Kao, JPY, Synthesis and biological testing of aminoxyls designed for long-term retention by living cells. Organic & Biomolecular Chemistry, 2005. 3(4): p. 645-648

Rosen, GM, Tsai, P, Weaver, J, Cao, GL, Pou, S, Roman, LJ, and Starkov, AA, L-Arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide. Biochemical Pharmacology, 2005. 69(6): p. 971-979

Tsai, P, Marra, JM, Pou, S, Bowman, MK, and Rosen, GM, Is there stereoselectivity in spin trapping superoxide by 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide? Journal of Organic Chemistry, 2005. 70(18): p. 7093-7097

Weaver, J, Porasuphatana, S, Tsai, P, Budzichowski, T, and Rosen, GM, Spin trapping nitric oxide from neuronal nitric oxide synthase: A look at several iron-dithiocarbamate complexes. Free Radical Research, 2005. 39(10): p. 1027-1033

Weaver, J, Porasuphatana, S, Tsai, P, Pou, S, Roman, LJ, and Rosen, GM, A comparative study of neuronal and inducible nitric oxide synthases: Generation of nitric oxide, superoxide, and hydrogen peroxide. Biochimica Et Biophysica Acta-General Subjects, 2005. 1726(3): p. 302-308

Williams, BB and Halpern, HJ, In Vivo EPR Imaging, in Biomedical EPR - Part A: Free Radicals, Metals, Medicine, and Physiology, SS Eaton, GR Eaton, and LJ Berliner, Editors. 2005, Kluwer Academic/Plenum Publishers: New York. p. 283-320.

Williams, BB, Pan, XC, and Halpern, HJ, EPR imaging: The relationship between CW spectra acquired from an extended sample subjected to fixed stepped gradients and the Radon transform of the resonance density. Journal of Magnetic Resonance, 2005. 174(1): p. 88-96

Elas, M, Ahn, KH, Parasca, A, Barth, ED, Lee, D, Haney, C, and Halpern, HJ, Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with oxylite oxygen measurements. Clinical Cancer Research, 2006. 12(14): p. 4209-4217

Haney, CR, Parasca, AD, Ichikawa, K, Williams, BB, Elas, M, Pelizzari, CA, and Halpern, HJ, Reduction of image artifacts in mice by bladder flushing with a novel double-lumen urethral catheter. Molecular Imaging, 2006. 5(3): p. 175-179

Hyde, JS, Eaton, SS, and Eaton, GR, EPR at work. Concepts in Magnetic Resonance Part A, 2006. 28A(1): p. 1-57

Liu, KJ, Shen, JG, Liu, SM, Miyake, M, Liu, WL, Pritchard, A, Kao, JPY, Rosen, GM, and Tong, Y, Use of 3-acetoxymethoxycarhonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl as an EPR oximetry probe: Potential for in vivo measurement of tissue oxygenation in mouse brain. Magnetic Resonance in Medicine, 2006. 55(6): p. 1433-1440

Mailer, C, Sundramoorthy, SV, Pelizzari, CA, and Halpern, HJ, Spin echo spectroscopic electron paramagnetic resonance imaging. Magnetic Resonance in Medicine, 2006. 55(4): p. 904-912

Porasuphatana, S, Weaver, J, and Rosen, GM, Inducible nitric oxide synthase catalyzes ethanol oxidation to alpha-hydroxyethyl radical and acetaldehyde. Toxicology, 2006. 223(3): p. 167-174

Quine, RW, Eaton, GR, and Dillon, S, Fast-response VHF pulsed 2 KW power amplifiers. Concepts in Magnetic Resonance Part B-Magnetic Resonance Engineering, 2006. 29B(4): p. 185-190.John Wiley & Sons Inc.

Rosen, GM, Miyake, M, Shen, JG, Liu, SM, Shi, HL, Liu, WL, Yuan, ZR, Pritchard, A, Kao, JPY, and Liu, KJ, Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O-2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. Journal of Pharmacology and Experimental Therapeutics, 2006.318(3): p. 1187-1193

Rosen, GM, Raines, KW, Kang, TJ, Hibbs, S, Cao, GL, Weaver, J, Tsai, P, Baillie, L, and Cross, AS, Importance of nitric oxide synthase in the control of infection by Bacillus anthracis. Infection and Immunity, 2006. 74(4): p. 2268-2276

Shapiro, P, Raines, KW, Cao, GL, Lee, EK, and Rosen, GM, Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity. Biochemical Journal, 2006. 397: p. 329-336

Tseitlin, M, Dhami, A, Quine, RW, Rinard, GA, Eaton, SS, and Eaton, GR, Electron spin T-2 of a nitroxyl radical at 250 MHz measured by rapid-scan EPR. Applied Magnetic Resonance, 2006. 30(3-4): p. 651-656

Weaver, JM, Raines, K, Porasuphatana, S, Tsai, P, Cao, GL, and Rosen, G, A comparative study of inducible and neuronal nitric oxide synthases. Faseb Journal, 2006. 20(5): p. A979-A979