Collaborations

Martyna Elas

Ph.D., D. Sc., Faculty of Biochemistry, Biophysics and Biotechnology
Jagiellonian University, Poland

Gronostajowa 7
30-387 Kraków, Poland

Our focus is anti-cancer therapy mechanisms in preclinical models, including radiotherapy (such as protontherapy) and phototherapy using new photosensitizers. For this goal we use non-invasive imaging methods, electron paramagnetic resonance oximetric imaging, ultrasonography and magnetic resonance imaging.

Link

Martyna Elas

Richard Kolesnick

Memorial Sloan-Kettering Cancer Center.

Center related project: Modulation of Ceramide-Induced apoptosis in vivo.

The Kolesnick lab uses two seprate animal models, C.elegans and Mus, to elucidate signalling throught Ceramide cascade and explore the organ/tissue distrobution of Ceramide's effects respectively. Pre-clinical data suggest that the therapeutic success of stereotactic radiosurgery, a new form of high dose radiotherapy capable of curing radioresistant cancer, depends on ceramide-mediated apoptosis of the tumor microvascular network. 

Link


Mrignayani Kotecha

University of Illinois in Chicago

Center related project: Correlating tumor hypoxia with fractional anisotropy using MRI and EPROI.

Link

Mrignayani Kotecha

Stephen Kron

University of Chicago

Professor, Molecular Genetics and Cell Biology, Committees on Genetics, Genomics and Systems Biology; Cancer Biology; Clinical Pharmacology and Pharmacogenomics

Center related project title: Radiation Response within the tumor microenvironment.

The Kron lab studies radiation enhanced permeability and retention, (R-EPR) an effect that may significantly improve the effectiveness of chemotherapies, radiation sensitizers, and other therapeutic adjuvants by improving delivery and extending retention in tumor tissue while minimizing the chemotherapeutic toxicity in normal tissue. 

Link


Gerald Rosen

Ph.D., J.D., Isaac E. Emerson Professor, Department of Pharmaceutical Sciences
University of Maryland School of Pharmacy

20 North Pine Street
Baltimore, Maryland 21201
Phone: (410) 706-0514
Fax: (410) 706-0886

Dr. Rosen received his Bachelor of Science in chemistry from Lowell Technological Institute in Lowell, MA, in 1965. He completed his doctorate in organic chemistry at the Clarkson College of Technology in Potsdam, NY, in 1969. In 1979, he graduated from the Duke University School of Law with his JD. Prior to joining the University of Maryland School of Pharmacy in 1988 as chair of the Department of Pharmacology and Toxicology, Dr. Rosen served as professor of pharmacology at Duke University. In 1990, he was appointed the Isaac E. Emerson Professor in the Department of Pharmaceutical Sciences at the School of Pharmacy.

Professor Gerald Rosen

Marsha Rosner

University of Chicago

Charles B. Huggins Professor, Ben May Department for Cancer Research.

Center Related Project: Hypoxia induces the BACH1 Cancer Invasion and Metastasis Trigger.

The Rosner Lab explores several signaling pathways involved in growth and metastasis of cancer. One of their key targets is the protein BACH1, a transcription factor implicated in cellular control of the redox state. The Rosner lab is investigating BACH1's potiental effect on the tumor microenviornment using the Center's EPRI technology. 

Link