Welcome to the Center for Electron Paramagnetic Resonance (EPR) Imaging in Vivo Physiology at the University of Chicago, a National Institutes of Biomedical Imaging and Bioengineering and NIH supported technology development resource. The aim of the Center is the development of new imaging technologies sensitive to the functioning of the normal and diseased tissues of living animals. The main focus of the Center is accurate and efficient imaging of molecular oxygen concentration in tissues. The Center's imaging technology exploits the unique, quantitative sensitivity of the EPR spectrum of soluble, injectable spin probes to crucial aspects of the fluids in which life processes evolve. The Center develops EPR instrumentation, spin probes and imaging methodologies. We use very low frequency EPR technology to maximize the depth in animal tissue to which the technique is sensitive. We have developed a wide range of methodologies to extract this information including pulse, continuous wave and Rapid Scan methodologies.
A film featuring the Center for EPR Imaging in vivo Physiology for 58th Annual Meeting of the Biophysical Society at the Moscone Center, San Francisco CA, 2014.